The article defines typhoid and the conditions that favor its growth and infection. Neurological symptoms play a  crucial role in the understanding of the infection of typhoid in the brainstem article plans different instances where typhoid can be introduced into the brain. It reviews different research that has been conducted with the focus of the infection on the bloodstream thus limited research on brain typhoid infection. It also provides an overview of one of the experiments performed with the aim of finding such symptoms in mice models. Having had a background knowledge on the primary symptoms of Salmonella infections the teams of researchers focus on monitoring changes such as those of fewer and inflammation which is often identified through the damage of the brain cells. Furthermore, through the previous encounters of genetic experiments the team was able to outline the mode of action of the bacteria in the brain, It described that salmonella proteins often play a role in breaking the blood-brain barrier thus getting access to the mind. With the curiosity of finding out the effect of treatment, the experiment wondered if the antibiotic would have similar results in treating neurological symptoms especially those associated with the bacteria Therefore after infecting the mice the researchers tried to prove the effects of antibiotics by injecting it to the infected mice. The procedure intended to kill the infectious bacteria by observing the performance of the mice.

On the contrary, the study showed minimal effects of antibiotics on the bacteria. However minimal improvement was noted in the same mice. Therefore, the findings in the study showed that Salmonella Enterica Typhi often has adverse effects when it infects the brain. Furthermore, it reduces brain performance and treatment with antibiotics has minimal effects.

O the other hand explains that salmonella infections calm thousands of lies. It describes it as one of the infectious microorganisms that causes systemic infections. On the other hand, the review similarly explored the mortality rates of symptoms and neurological damage linked to typhoid. It studied, a different strain of salmonella with a focus on identifying its effects on the brain. Salmonella Typhimurium infection was shown to have an intensive effect unlike the case of Salmonella enterica. Besides, it was demonstrated that antibiotics do not entirely cure it. To approve this, the study was conducted by taking two strains of mouse and subjected to doses of S. Typhimurium. The concentration of the bacteria in the brain were shown to increase especially in the brain cortex and midbrain. Therefore the study showed that the asteria could reach one or more parts of the brain.

Immunotherapy techniques were further used to determine the presence of antibiotics in the brain. The invasion by Salmonella  Typhimurium It introduces the fact that the bacteria can also be attributed to its virulent factors such as Virulence plasmid and the SPI mutating. The SPI mutant was shown to have the capability of crossing through the blood-brain barrier. The SPI aids in the process of moving the bacteria to the vital parts of the brain

Besides the neurological manifestation of mice was shown to cause abnormalities that be physically monitored through their movements They typhoid symptoms were analyzed based on the ability  to reoccur after the incidents Based on the rate of bacterial load in the brain it is critical to identify the significant effects of different forms of antibiotics.

 
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