Over the years, there have been increased efforts from different stakeholders to try and discover a definite treatment for cancer given that it has been a menace and resulted in numerous deaths. Several platinum compounds including Cisplatin are currently being used as anticancer drugs. However, it has been noted that some cancer types such as ovarian cancer tend to become resistant to cisplatin chemotherapy. The study intends to get an understanding of how the ovarian cells remain resistant to cisplatin. This will help in identification of new interventions that ovarian cancer will not be resistant to. For this to be achieved, the study has to understand the regions of the genome where the resistance occurs. There was an initial study of the global genome levels responsible for damage and repair. The study used a variant comet assay in a chemoresistant (SKOV-3) and a chemosensitive (OCP- P5x and A2780) ovarian cell lines. By using comet assay, data obtained from the study gave an indication of considerable differences in DNA tails and DNA tail moments between these ovarian cell lines. Some of the methodologies in the study were optimized through a human keratinocyte cell (HaCaTs) model.

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